Article
Inducible dimerization of RET reveals a specific AKT deregulation in oncogenic signaling.
The Journal of biological chemistry - 4 Nov 2005
Frêche Barbara, Guillaumot Patricia, Charmetant Julie, Pelletier Ludivine, Luquain Celine, Christiansen Dale, Billaud Marc, Manié Serge N
Abstract excerpt
Dominant-activating mutations in the RET (rearranged during transfection) proto-oncogene, a receptor tyrosine kinase, are causally associated with the development of multiple endocrine neoplasia type 2A (MEN2A) syndrome. Such oncogenic RET mutations induce its ligand-independent constitutive activation, but whether it spreads identical signaling to ligand-induced signaling is uncertain. To address this question,...
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