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Article

Assessing the effect of RET transmembrane domain mutations in receptor self-association capability using the in vivo TOXCAT system.

Neoplasma - 1 Jan 2013

Benej M, Fekecsova S, Poturnajova M

Abstract excerpt

Mutations of c-RET proto-oncogene with a unique localization within the human transmembrane receptor represent a challenge for contemporary molecular oncology techniques. RET transmembrane domain (TMD)-driven dimerization of the receptor leads to its permanent activation that eventually results in the development of medullary thyroid neoplasia. In this study, we describe the employment of the TOXCAT system which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23067224
DOI: 10.4149/neo_2013_015

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Assessing the effect of RET transmembrane domain mutations in receptor self-association capability using the in vivo TOXCAT system.PMID 23067224Read ↗

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