Article
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
The Journal of biological chemistry - 13 May 2011
Plaza-Menacho Iván, Morandi Andrea, Mologni Luca, Boender Piet, Gambacorti-Passerini Carlo, Magee Anthony I, Hofstra Robert M W, Knowles Phillip, McDonald Neil Q, Isacke Clare M
Abstract excerpt
Whether RET is able to directly phosphorylate and activate downstream targets independently of the binding of proteins that contain Src homology 2 or phosphotyrosine binding domains and whether mechanisms in trans by cytoplasmic kinases can modulate RET function and signaling remain largely unexplored. In this study, oligopeptide arrays were used to screen substrates directly phosphorylated by purified...
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