Article
Differential membrane compartmentalization of Ret by PTB-adaptor engagement.
The FEBS journal - 1 May 2008
Lundgren T K, Luebke Moritz, Stenqvist Anna, Ernfors Patrik
Abstract excerpt
Glial cell line-derived neurotrophic factor family ligands act through the receptor tyrosine kinase Ret, which plays important roles during embryonic development for cell differentiation, survival, and migration. Ret signaling is markedly affected by compartmentalization of receptor complexes into membrane subdomains. Ret can propagate biochemical signaling from within concentrates in cholesterol-rich membrane...
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