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Article

Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005

Gutterman Jordan U, Lai Hong T, Yang Peirong, Haridas Valsala, Gaikwad Amos, Marcus Stevan

Abstract excerpt

Avicins comprise a class of triterpenoid compounds that exhibit tumor inhibitory activity. Here we show that avicin G is inhibitory to growth of the fission yeast Schizosaccharomyces pombe. S. pombe cells treated with a lethal concentration of avicin G (20 microM) exhibited a shrunken morphology, indicating that avicin G adversely affects cell integrity. Cells treated with a sublethal concentration of avicin G...

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Identifiers

PMID: 16118282
DOI: 10.1073/pnas.0505758102
PMCID: PMC1200287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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