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Article

Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

PloS one - 1 Jan 2011

Takeda Kojiro, Mori Ayaka, Yanagida Mitsuhiro

Abstract excerpt

Bortezomib/PS-341/Velcade, a proteasome inhibitor, is widely used to treat multiple myeloma. While several mechanisms of the cytotoxicity of the drug were proposed, the actual mechanism remains elusive. We aimed to identify genes affecting the cytotoxicity of Bortezomib in the fission yeast S. pombe as the drug inhibits this organism's cell division cycle like proteasome mutants. Among the 2815 genes screened...

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Identifiers

PMID: 21760946
DOI: 10.1371/journal.pone.0022021
PMCID: PMC3132776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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