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Article

Fredericamycin A affects mitochondrial inheritance and morphology in Saccharomyces cerevisiae.

Bioscience, biotechnology, and biochemistry - 1 Nov 2005

Imamura Yuko, Yukawa Masashi, Kimura Ken-ichi, Takahashi Hidetoshi, Suzuki Yoshihiro, Ojika Makoto, Sakagami Youji, Tsuchiya Eiko

Abstract excerpt

Fredericamycin A (FMA) is an antibiotic product of Streptomyces griseus that exhibits modest antitumor activity in vivo and in vitro, but, its functions in vivo are poorly understood. We identified this compound as an inducer of G1 arrest in the yeast, Saccharomyces cerevisiae. FMA exhibits an IC50 of 24 nM towards the growth of a disruptant of multi-drug resistance genes, W303-MLC30, and its cytotoxicity is a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16306705
DOI: 10.1271/bbb.69.2213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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