Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects

18 Aug 2021

Abstract excerpt

To identify novel bioactive compounds, an image-based, cell culture screening of natural product extracts was conducted. Specifically, our screen was designed to identify phytochemicals that might phenocopy inhibition of the chromosomal passenger protein complex in eliciting mitotic and cytokinetic defects. A known alkaloid, scoulerine, was identified from the rhizomes of the plant Corydalis decumbens as being...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer therapeutics and mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34406008
DOI: 10.1021/acs.jnatprod.1c00429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic DefectsPMID 34406008Read ↗

Mitotic Poisons In Cancer PharmacotherapySemantic proximity Read ↗

Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen.Semantic proximity Read ↗

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Semantic proximity Read ↗

A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cellsSemantic proximity Read ↗

New Cell Cycle Inhibitors Target Aneuploidy in Cancer TherapySemantic proximity Read ↗

Mitotic Poisons in Research and MedicineSemantic proximity Read ↗

Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer CellsSemantic proximity Read ↗

Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor EfficacySemantic proximity Read ↗

Mitosis-targeted anti-cancer therapies: where they standSemantic proximity Read ↗

Identification of novel small molecule inhibitors of centrosome clustering in cancer cellsSemantic proximity Read ↗

CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cellsSemantic proximity Read ↗

Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.