Evidence for the Mode of Action of the Highly Cytotoxic <i>Streptomyces</i> Polyketide Kendomycin

Abstract excerpt

The macrocyclic polyketide kendomycin exhibits antiosteoporotic and antibacterial activity, as well as strong cytotoxicity against multiple human tumor cell lines. Despite the promise of this compound in several therapeutic areas, the cellular target(s) of kendomycin have not been identified to date. We have used a number of approaches, including microscopy, proteomics, and bioinformatics, to investigate the mode...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell death mechanisms and regulation
• Share to Peptidase Inhibition and Analysis
• Share to Ubiquitin and proteasome pathways