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Article

HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.

Molecular biology of the cell - 1 Apr 2004

Chang Fred, Re Fabio, Sebastian Sarah, Sazer Shelley, Luban Jeremy

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) Vpr is a 15-kDa accessory protein that contributes to several steps in the viral replication cycle and promotes virus-associated pathology. Previous studies demonstrated that Vpr inhibits G2/M cell cycle progression in both human cells and in the fission yeast Schizosaccharomyces pombe. Here, we report that, upon induction of vpr expression, fission yeast exhibited...

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Identifiers

PMID: 14767062
DOI: 10.1091/mbc.e03-09-0691
PMCID: PMC379276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.PMID 14767062Read ↗

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