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Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants.

Investigational new drugs - 1 Aug 2008

Chung Kyung-Sook, Yim Nam-Hui, Lee Seung-Hee, Choi Shin-Jung, Hur Kyung-Sun, Hoe Kwang-Lae, Kim Dong-Uk, Goehle Sondra, Kim Hyung-Bae, Song Kyung-Bin, Yoo Hyang-Sook, Bae Ki-Hwan, Simon Julian, Won Misun

Abstract excerpt

The cell-based assay using yeast deletion mutants has been recognized as an efficient analysis to discover therapeutic compounds and reveal their mode of action. In this study, S. pombe deletion mutants-based HTS screening was carried out to identify potential anti-cancer agents. The NCI chemical library of 5700 compounds was screened using kit strains, which consisted of S. pombe mutants harboring deletions in...

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PMID: 18204818
DOI: 10.1007/s10637-007-9100-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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