Article
FLT3 mutations in canine acute lymphocytic leukemia.
BMC cancer - 27 Jan 2011
Suter Steven E, Small George W, Seiser Eric L, Thomas Rachael, Breen Matthew, Richards Kristy L
Abstract excerpt
BACKGROUND: FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembrane domain (ITD), result in continuous cellular proliferation, resistance to apoptotic cell death, and a poorer prognosis. A better understanding of the molecular consequences of FLT3 activation...
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