Article
Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cells.
Neuroscience letters - 16 Dec 2005
Nishinaga Hiromi, Takahashi-Niki Kazuko, Taira Takahiro, Andreadis Athena, Iguchi-Ariga Sanae M M, Ariga Hiroyoshi
Abstract excerpt
DJ-1 is a novel oncogene and a causative gene for the familial form of Parkinson's disease (PD). DJ-1 has been shown to play roles in anti-oxidative stress by eliminating reactive oxygen species and in transcriptional regulation of genes. Loss of these functions of DJ-1 is thought to trigger the onset of PD. In this study, to identify genes for which expressions are regulated by DJ-1, DNA microarray analyses were...
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