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Article

Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.

Neurotoxicology - 1 May 2008

Lev Nirit, Ickowicz Debby, Melamed Eldad, Offen Daniel

Abstract excerpt

Oxidative stress is implicated in the pathogenesis of central nervous system damage in neurodegenerative diseases as well as in normal aging. Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases caused by both environmental and inherited factors. DJ-1 mutation...

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Identifiers

PMID: 18377993
DOI: 10.1016/j.neuro.2008.01.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18377993-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.PMID 18377993Read ↗

DJ-1 has a role in antioxidative stress to prevent cell death.Semantic proximity Read ↗

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.Semantic proximity Read ↗

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangleSemantic proximity Read ↗

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.Semantic proximity Read ↗

DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE).Semantic proximity Read ↗

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s DiseaseSemantic proximity Read ↗

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neuronsSemantic proximity Read ↗

DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative StressSemantic proximity Read ↗

Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress.Semantic proximity Read ↗

The Parkinson's-associated protein DJ-1 regulates the 20S proteasome.Semantic proximity Read ↗

Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.Semantic proximity Read ↗

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.Semantic proximity Read ↗

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