Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress.

Redox biology - 1 Oct 2018

Oh Stephanie E, Park Hye-Jin, He Liqiang, Skibiel Catherine, Junn Eunsung, Mouradian M Maral

Abstract excerpt

DJ-1 is a highly conserved protein that protects neurons against oxidative stress and whose loss of function mutations are linked to recessively inherited Parkinson's disease (PD). While a number of signaling pathways have been shown to be regulated by DJ-1, its role in controlling cell survival through non-coding RNAs remains poorly understood. Here, using a microarray screen, we found that knocking down DJ-1 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to MAP Kinase Signaling System

Share to MicroRNAs

Share to Oxidative Stress

Share to Parkinson Disease

Share to Protein Deglycase DJ-1

Source

Open in PubMed Open full text

Identifiers

PMID: 30107296
DOI: 10.1016/j.redox.2018.07.021
PMCID: PMC6092527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress.PMID 30107296Read ↗

miR-221 and Parkinson’s disease: A biomarker with therapeutic potentialSemantic proximity Read ↗

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.Semantic proximity Read ↗

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.Semantic proximity Read ↗

Role of DJ-1 in Parkinson's disease.Semantic proximity Read ↗

DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative StressSemantic proximity Read ↗

MiR-421 Aggravates Neurotoxicity and Promotes Cell Death in Parkinson’s Disease Models by Directly Targeting MEF2DSemantic proximity Read ↗

Parkinson disease-associated protein DJ-1 regulates the autophagic-lysosomal pathway through ROS-dependent modulation of the AMPK/mTORC1 axisSemantic proximity Read ↗

DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death.Semantic proximity Read ↗

Modulation of signaling pathways by DJ-1: An updated overviewSemantic proximity Read ↗

DJ-1: A New Comer in Parkinsons Disease PathologySemantic proximity Read ↗

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondriaSemantic proximity Read ↗

MicroRNA-221: A Context-Dependent Mediator in Human Diseases—From Molecular Mechanisms to Clinical TranslationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.