Article
Expression profiles of genes in wild-type DJ-1 and A39S DJ-1 mutant cells.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 Apr 2014
Liu Zhenhua, Tang Beisha, He Dan, Wang Lei, Xiao Zhiquan, Yan Xinxiang, Guo Jifeng
Abstract excerpt
OBJECTIVE: To elucidate the role of A39S mutation of DJ-1 in the onset of Parkinson's disease (PD) and identify genes for which expressions are abnormally regulated by A39S DJ-1 mutation. METHODS: We established HEK293 cell lines which stably expressed empty vector, wild-type DJ-1 and A39S mutated DJ-1 respectively. DNA microarrays were used to identify genes for which expressions change in wild-type DJ-1 cells...
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