Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes.

Human biology - 1 Feb 2005

Almasy Laura, Rainwater David L, Cole Shelley, Mahaney Michael C, Vandeberg John L, Hixson James E, Stern Michael P, MacCluer Jean W, Blangero John

Abstract excerpt

The hepatic lipase gene (LIPC) has been implicated as a potential regulator of HDL-cholesterol concentration and HDL and LDL particle size. Studies have centered on a C to T transition in the promoter region of LIPC, 514 base pairs upstream from the transcription initiation site. We performed a genome-wide linkage screen for several lipoprotein size phenotypes and tested for association of these traits with LIPC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, HDL
Share to Cholesterol, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipase

Share to Mexican Americans

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 16114813
DOI: 10.1353/hub.2005.0025

Genes

LIPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes.PMID 16114813Read ↗

LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.Semantic proximity Read ↗

Evidence for a major quantitative trait locus on chromosome 17q21 affecting low-density lipoprotein peak particle diameter.Semantic proximity Read ↗

Large-scale candidate gene analysis of HDL particle features.Semantic proximity Read ↗

Low-density lipoprotein particle size loci in familial combined hyperlipidemia: evidence for multiple loci from a genome scan.Semantic proximity Read ↗

Functional Characterization of LIPA (Lysosomal Acid Lipase) Variants Associated With Coronary Artery Disease.Semantic proximity Read ↗

Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia.Semantic proximity Read ↗

A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins.Semantic proximity Read ↗

Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity.Semantic proximity Read ↗

Identification of promoter variants in baboon endothelial lipase that regulate high-density lipoprotein cholesterol levels.Semantic proximity Read ↗

A genome search identifies major quantitative trait loci on human chromosomes 3 and 4 that influence cholesterol concentrations in small LDL particles.Semantic proximity Read ↗

Variation near the region of the lipoprotein lipase gene and hypertension or blood pressure levels in Chinese.Semantic proximity Read ↗

Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.