Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

The EMBO journal - 21 Sept 2005

Wang Chuangui, Ivanov Alexey, Chen Lihong, Fredericks William J, Seto Ed, Rauscher Frank J, Chen Jiandong

Abstract excerpt

MDM2 is a RING domain ubiquitin E3 ligase and a major regulator of the p53 tumor suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 acetylation, and promotes p53 degradation. Here, we present evidence that MDM2 interacts with the nuclear corepressor KAP1. The binding is mediated by the N-terminal coiled-coil domain of KAP1 and the central acidic domain of MDM2. KAP1 stimulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cell Nucleus
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase 1

Share to Histone Deacetylases

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-mdm2

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 16107876
DOI: 10.1038/sj.emboj.7600791
PMCID: PMC1224681

Genes

MDM2
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.PMID 16107876Read ↗

The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes.Semantic proximity Read ↗

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.Semantic proximity Read ↗

MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer CellsSemantic proximity Read ↗

Critical Roles of DMP1 in Human Epidermal Growth Factor Receptor 2/neu-Arf-p53 Signaling and Breast Cancer DevelopmentSemantic proximity Read ↗

The MDM2 C-terminal Region Binds to TAFII250 and Is Required for MDM2 Regulation of the Cyclin A PromoterSemantic proximity Read ↗

Post-Translational Regulation of ARF: Perspective in CancerSemantic proximity Read ↗

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.Semantic proximity Read ↗

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.Semantic proximity Read ↗

The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 stabilitySemantic proximity Read ↗

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.Semantic proximity Read ↗

cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation.Semantic proximity Read ↗

Inhibition of p53 degradation by Mdm2 acetylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.