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Article

cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation.

Cell cycle (Georgetown, Tex.) - 1 Nov 2012

Lau Rosanna, Niu Min Ying, Pratt M A Christine

Abstract excerpt

Cellular inhibitor of apoptosis proteins (cIAP1 and cIAP2) function to prevent apoptosis and are often overexpressed in various cancers. However, mutations in cIAP1/2 can activate the alternative NFκB pathway through IκBα-kinase-α (IKKα) and are associated with hematopoetic malignancies. In the current study, we found that knockdown of cIAP2 in human mammary epithelial cells resulted in activation of MDM2 through...

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Source

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Identifiers

PMID: 23032264
DOI: 10.4161/cc.22223
PMCID: PMC3507496

Genes

MDM2
PIAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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