Article
The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes.
The Journal of biological chemistry - 23 Feb 2018
Ding Dong, Bergmaier Philipp, Sachs Parysatis, Klangwart Marius, Rückert Tamina, Bartels Nora, Demmers Jeroen, Dekker Mike, Poot Raymond A, Mermoud Jacqueline E
Abstract excerpt
Chromatin in embryonic stem cells (ESCs) differs markedly from that in somatic cells, with ESCs exhibiting a more open chromatin configuration. Accordingly, ATP-dependent chromatin remodeling complexes are important regulators of ESC homeostasis. Depletion of the remodeler SMARCAD1, an ATPase of the SNF2 family, has been shown to affect stem cell state, but the mechanistic explanation for this effect is unknown....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.