Article
p53 mutant mice that display early ageing-associated phenotypes.
Nature - 3 Jan 2002
Tyner Stuart D, Venkatachalam Sundaresan, Choi Jene, Jones Stephen, Ghebranious Nader, Igelmann Herbert, Lu Xiongbin, Soron Gabrielle, Cooper Benjamin, Brayton Cory, Park Sang Hee, Thompson Timothy, Karsenty Gerard, Bradley Allan, Donehower Lawrence A
Abstract excerpt
The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than...
Topics
- Adipose Tissue
- Aging
- Aging, Premature
- Alleles
- Animals
- Body Weight
- Bone and Bones
- Cell Transformation, Neoplastic
- Cells, Cultured
- Exons