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Article

DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse.

Cell cycle (Georgetown, Tex.) - 1 Sept 2006

Sommer Matthias, Poliak Nina, Upadhyay Sunil, Ratovitski Edward, Nelkin Barry D, Donehower Lawrence A, Sidransky David

Abstract excerpt

p63 is highly expressed in the skin and appears to be an early marker of keratinocyte differentiation. To examine the role of p63 in vivo, we generated transgenic mice that overexpress deltaNp63alpha in the skin. These mice exhibited an accelerated aging phenotype in the skin characterized by str...

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Identifiers

PMID: 16940753
DOI: 10.4161/cc.5.17.3194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16940753-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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