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Article

Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS.

Journal of neurology, neurosurgery, and psychiatry - 1 Sept 2005

Turner M R, Osei-Lah A D, Hammers A, Al-Chalabi A, Shaw C E, Andersen P M, Brooks D J, Leigh P N, Mills K R

Abstract excerpt

BACKGROUND: Excitotoxicity is one pathogenic mechanism proposed in amyotrophic lateral sclerosis (ALS), and loss of cortical inhibitory influence may be contributory. Patients with ALS who are homozygous for the D90A superoxide dismutase-1 (SOD1) gene mutation (homD90A) have a unique phenotype, associated with prolonged survival compared with patients with sporadic ALS (sALS). In this study, transcranial magnetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16107368
DOI: 10.1136/jnnp.2004.054429
PMCID: PMC1739803

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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