Article
A novel central motor conduction abnormality in D90A-homozygous patients with amyotrophic lateral sclerosis.
Muscle & nerve - 1 Jun 2004
Osei-Lah Abena D, Turner Martin R, Andersen Peter M, Leigh P Nigel, Mills Kerry R
Abstract excerpt
Patients with amyotrophic lateral sclerosis (ALS) who are homozygous for the D90A SOD1 mutation have been noted to have central motor abnormalities distinct from those of patients with idiopathic ALS. We stimulated the motor cortex of ten patients homozygous for the D90A SOD1 mutation, using transcranial magnetic stimulation (TMS), and recorded the response evoked in the right first dorsal interosseous muscle...
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