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Article

Upregulation of persistent sodium conductances in familial ALS

2 Sept 2009

Abstract excerpt

BACKGROUND: Upregulation of persistent Na(+) conductances has been linked to axonal degeneration in sporadic amyotrophic lateral sclerosis (ALS) and has also been reported in the transgenic superoxide dismutase-1 (SOD-1) mouse model. The mechanisms of ectopic activity (fasciculations and cramp) and axonal degeneration still require clarification in familial ALS (FALS) in humans, and specifically whether there are...

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PMID: 19726402
DOI: 10.1136/jnnp.2009.183079

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