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Article

Cortical inexcitability in ALS: correlating a clinical phenotype.

Journal of neurology, neurosurgery, and psychiatry - 13 Mar 2025

Pavey Nathan, Hannaford Andrew, Higashihara Mana, van den Bos Mehdi, Geevasinga Nimeshan, Vucic Steve, Menon Parvathi

Abstract excerpt

BACKGROUND: Cortical inexcitability, a less studied feature of upper motor neuron (UMN) dysfunction in amyotrophic lateral sclerosis (ALS), was identified in a large cross-sectional cohort of ALS patients and their demographic and clinical characteristics were contrasted with normal or hyperexcitable ALS cohorts to assess the impact of cortical inexcitability on ALS phenotype and survival. METHODS:...

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Identifiers

PMID: 39137976
DOI: 10.1136/jnnp-2024-333928
PMCID: PMC12015075

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