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Article

Cortical excitability changes distinguish the motor neuron disease phenotypes from hereditary spastic paraplegia.

European journal of neurology - 1 May 2015

Geevasinga N, Menon P, Sue C M, Kumar K R, Ng K, Yiannikas C, Kiernan M C, Vucic S

Abstract excerpt

BACKGROUND AND PURPOSE: Cortical hyperexcitability has been identified as an important pathogenic mechanism in motor neuron disease (MND). The issue as to whether cortical hyperexcitability is a common process across the MND phenotypes, including amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS), remains unresolved. Separately, the clinical distinction between PLS and 'mimic disorders' such...

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Identifiers

PMID: 25683471
DOI: 10.1111/ene.12669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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