Corticomotoneuronal dysfunction in ALS patients with different SOD1 mutations.

doi:10.1016/j.clinph.2006.04.004

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Corticomotoneuronal dysfunction in ALS patients with different SOD1 mutations.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 1 Aug 2006

Stewart Heather G, Andersen Peter M, Eisen Andrew, Weber Markus

Abstract excerpt

OBJECTIVE: To examine corticomotoneuronal function in amyotrophic lateral sclerosis (ALS) patients carrying superoxide dismutase 1 (SOD1) mutations using peristimulus time histograms (PSTH). METHODS: Six I113T, 3 A4V, one G41D and one G114A patient were studied along with 21 healthy control subjects. Analyses included comparison with previously reported data from 8 D90A homozygous and 12 sporadic ALS (SALS)...

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Corticomotoneuronal dysfunction in ALS patients with different SOD1 mutations.

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