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Article

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis.

Brain : a journal of neurology - 1 Jun 2008

Vucic Steve, Nicholson Garth A, Kiernan Matthew C

Abstract excerpt

Familial amyotrophic lateral sclerosis (FALS) is an inherited neurodegenerative disorder of the motor neurons. While 10-15% of cases are caused by mutations in the copper/zinc superoxide-dismutase-1 (SOD-1) gene, the dying-forward hypothesis, in which corticomotoneurons induce anterograde excitotoxic motoneuron degeneration, has been proposed as a potential mechanism. The present study applied novel threshold...

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Source

Identifiers

PMID: 18469020
DOI: 10.1093/brain/awn071

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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