Article
Motor cortical excitability predicts cognitive phenotypes in amyotrophic lateral sclerosis.
Scientific reports - 26 Jan 2021
Agarwal Smriti, Highton-Williamson Elizabeth, Caga Jashelle, Howells James, Dharmadasa Thanuja, Matamala José M, Ma Yan, Shibuya Kazumoto, Hodges John R, Ahmed Rebekah M, Vucic Steve, Kiernan Matthew C
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are well-recognised as an extended disease spectrum. This study hypothesised that cortical hyperexcitability, an early pathophysiological abnormality in ALS, would distinguish cognitive phenotypes, as a surrogate marker of pathological disease burden. 61 patients with ALS, matched for disease duration (pure motor ALS, n = 39; ALS with...
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