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Article

Azathioprine-induced carcinogenesis in mice according to Msh2 genotype.

Journal of the National Cancer Institute - 17 Nov 2010

Chalastanis Alexandra, Penard-Lacronique Virginie, Svrcek Magali, Defaweux Valérie, Antoine Nadine, Buhard Olivier, Dumont Sylvie, Fabiani Bettina, Renault Isabelle, Tubacher Emmanuel, Fléjou Jean-François, Te Riele Hein, Duval Alex, Muleris Martine

Abstract excerpt

BACKGROUND: The thiopurine prodrug azathioprine is used extensively in cancer therapy. Exposure to this drug results in the selection of DNA mismatch repair-deficient cell clones in vitro. It has also been suggested that thiopurine drugs might constitute a risk factor for the emergence of human neoplasms displaying microsatellite instability (MSI) because of deficient DNA mismatch repair. METHODS: Azathioprine...

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Identifiers

PMID: 20923998
DOI: 10.1093/jnci/djq389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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