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Article

Intracellular <i>Salmonella</i> Inhibit Antigen Presentation by Dendritic Cells

1 Mar 2005

Abstract excerpt

Dendritic cells (DC) are important APCs linking innate and adaptive immunity. During analysis of the intracellular activities of Salmonella enterica in DC, we observed that viable bacteria suppress Ag-dependent T cell proliferation. This effect was dependent on the induction of inducible NO synthase by DC and on the function of virulence genes in Salmonella pathogenicity island 2 (SPI2). Intracellular activities...

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PMID: 15728500
DOI: 10.4049/jimmunol.174.5.2892

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