Article
Autism and the serotonin transporter: the long and short of it.
Molecular psychiatry - 1 Dec 2005
Devlin B, Cook E H, Coon H, Dawson G, Grigorenko E L, McMahon W, Minshew N, Pauls D, Smith M, Spence M A, Rodier P M, Stodgell C, Schellenberg G D
Abstract excerpt
Autism is a neurodevelopmental disorder manifesting early in childhood. Some symptoms of autism are alleviated by treatment with selective serotonin reuptake inhibitors, which are known to interact with the serotonin transporter. Moreover, variation in the gene that encodes the transporter (SLC6A4), especially the HTTLPR locus, is known to modulate its expression. It is natural, therefore, to evaluate whether...
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