Article
Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic population.
Molecular psychiatry - 1 Jun 2004
Conroy J, Meally E, Kearney G, Fitzgerald M, Gill M, Gallagher L
Abstract excerpt
The role of the serotonin transporter (5-HTT) in the development of neuropsychiatric disorders has been widely investigated. Two polymorphisms, an insertion/deletion in the promoter region and a 12 repeat allele in a variable nucleotide tandem repeat (VNTR) in intron 2, drive higher expression of the 5-HTT gene. Four studies have shown nominally significant excess transmission of alleles of the 5-HTT gene in...
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