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Article

Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Aug 2013

Singh Asem Surindro, Chandra Rashmi, Guhathakurta Subhrangshu, Sinha Swagata, Chatterjee Anindita, Ahmed Shabina, Ghosh Saurabh, Rajamma Usha

Abstract excerpt

BACKGROUND: Serotoninergic dysfunction leads to neurodevelopmental abnormalities and behavioral impairments. Platelet hyperserotoninemia is reported as the best identified endophenotype for autism spectrum disorders. Therefore, in the present study we investigate the association of TPH2, the rate limiting enzyme in 5-HT biosynthesis and ITGB3, a serotonin quantitative trait locus with ASD in the Indian...

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Identifiers

PMID: 23628433
DOI: 10.1016/j.pnpbp.2013.04.015

Genes

ITGB3
TPH2

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