Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism.

doi:10.1017/S1461145708009036

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Article

Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism.

The international journal of neuropsychopharmacology - 1 Dec 2008

Nakamura Kazuhiko, Anitha Ayyappan, Yamada Kazuo, Tsujii Masatsugu, Iwayama Yoshimi, Hattori Eiji, Toyota Tomoko, Suda Shiro, Takei Noriyoshi, Iwata Yasuhide, Suzuki Katsuaki, Matsuzaki Hideo, Kawai Masayoshi, Sekine Yoshimoto, Tsuchiya Kenji J, Sugihara Gen-Ichi, Ouchi Yasuomi, Sugiyama Toshiro, Yoshikawa Takeo, Mori Norio

Abstract excerpt

Autism is a pervasive developmental disorder diagnosed in early childhood. Abnormalities of serotonergic neurotransmission have been reported in autism. Serotonin transporter (5-HTT), which modulates serotonin levels, is a major therapeutic target in autism. Therefore, factors that regulate 5-HTT expression might be implicated in autism. One candidate 5-HTT-regulatory protein is the presynaptic protein, syntaxin...

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PMID: 18593506
DOI: 10.1017/S1461145708009036

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