Article
Role of the serotonin transporter gene in the behavioral expression of autism.
Molecular psychiatry - 1 Jul 2001
Tordjman S, Gutknecht L, Carlier M, Spitz E, Antoine C, Slama F, Carsalade V, Cohen D J, Ferrari P, Roubertoux P L, Anderson G M
Abstract excerpt
The promoter polymorphism of the serotonin transporter gene (HTT, locus SLC6A4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. Parent-offspring transmission of the long (l) and short (s) alleles of the deletion/insertion polymorphism in the HTT...
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