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Article

A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2006

Mahon Matthew J, Bonacci Tabetha M, Divieti Paola, Smrcka Alan V

Abstract excerpt

The G protein-coupled receptor for PTH and PTH-related protein (PTH1R) signals via many intracellular pathways. The purpose of this work is to investigate a G protein binding site on an intracellular domain of the PTH1R. The carboxy-terminal, cytoplasmic tail of the PTH1R fused to glutathione-S-transferase interacts with Gi/o proteins in vitro. All three subunits of the heterotrimer interact with the receptor...

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Share to Adenylyl Cyclases
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein beta Subunits

Share to GTP-Binding Protein gamma Subunits

Share to Guanosine 5'-O-(3-Thiotriphosphate)

Share to Phospholipase C beta

Share to Receptor, Parathyroid Hormone, Type 1

Share to Type C Phospholipases

Source

Identifiers

PMID: 16099817
DOI: 10.1210/me.2005-0169

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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