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Analysis of Ribavirin Mutagenicity in Human Hepatitis C Virus Infection

10 May 2007

Abstract excerpt

The addition of ribavirin to alpha interferon therapy significantly increases response rates for patients with chronic hepatitis C virus (HCV) infection, but ribavirin's antiviral mechanisms are unknown. Ribavirin has been suggested to have mutagenic potential in vitro that would lead to "error catastrophe," i.e., the generation of nonviable viral quasispecies due to the increment in the number of mutant genomes,...

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PMID: 17494069
DOI: 10.1128/jvi.00382-07

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