Article
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69.
Respiratory research - 14 Aug 2005
Amicosante Massimo, Berretta Floriana, Rossman Milton, Butler Richard H, Rogliani Paola, van den Berg-Loonen Ella, Saltini Cesare
Abstract excerpt
BACKGROUND: Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP beta-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR alleles and polymorphisms. However, no genetic associations have been found be...
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