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Article

Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2015

Zhang Jian, Lieu Yen K, Ali Abdullah M, Penson Alex, Reggio Kathryn S, Rabadan Raul, Raza Azra, Mukherjee Siddhartha, Manley James L

Abstract excerpt

Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with myelodysplastic syndromes and certain leukemias, but how these mutations affect SRSF2 function has only begun to be examined. We used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26261309
DOI: 10.1073/pnas.1514105112
PMCID: PMC4553800

Genes

SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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