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Article

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.

Molecular cell - 1 Feb 2018

Chen Liang, Chen Jia-Yu, Huang Yi-Jou, Gu Ying, Qiu Jinsong, Qian Hao, Shao Changwei, Zhang Xuan, Hu Jing, Li Hairi, He Shunmin, Zhou Yu, Abdel-Wahab Omar, Zhang Dong-Er, Fu Xiang-Dong

Abstract excerpt

Mutations in several general pre-mRNA splicing factors have been linked to myelodysplastic syndromes (MDSs) and solid tumors. These mutations have generally been assumed to cause disease by the resultant splicing defects, but different mutations appear to induce distinct splicing defects, raising the possibility that an alternative common mechanism is involved. Here we report a chain of events triggered by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29395063
DOI: 10.1016/j.molcel.2017.12.029
PMCID: PMC5957072

Genes

SRSF2
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.PMID 29395063Read ↗

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