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Article

PIN1 gene variants in Alzheimer's disease.

BMC medical genetics - 12 Nov 2009

Maruszak Aleksandra, Safranow Krzysztof, Gustaw Katarzyna, Kijanowska-Haładyna Beata, Jakubowska Katarzyna, Olszewska Maria, Styczyńska Maria, Berdyński Mariusz, Tysarowski Andrzej, Chlubek Dariusz, Siedlecki Janusz, Barcikowska Maria, Zekanowski Cezary

Abstract excerpt

BACKGROUND: Peptidyl-prolyl isomerase, NIMA-interacting 1 (PIN1) plays a significant role in the brain and is implicated in numerous cellular processes related to Alzheimer's disease (AD) and other neurodegenerative conditions. There are confounding results concerning PIN1 activity in AD brains....

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Source

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Identifiers

PMID: 19909517
DOI: 10.1186/1471-2350-10-115
PMCID: PMC2781804

Genes

PIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19909517-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIN1 gene variants in Alzheimer's disease.PMID 19909517Read ↗

Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease.Semantic proximity Read ↗

DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer's disease.Semantic proximity Read ↗

PIN1 promoter polymorphisms are associated with Alzheimer's disease.Semantic proximity Read ↗

Association study of the PIN1 gene with Alzheimer's disease.Semantic proximity Read ↗

PIN1-842G/C and -667T/C polymorphisms are not associated with the susceptibility of Alzheimer's disease: pooled analysis of epidemiologic studies.Semantic proximity Read ↗

Pin1 contribution to Alzheimer's disease: transcriptional and epigenetic mechanisms in patients with late-onset Alzheimer's disease.Semantic proximity Read ↗

A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.Semantic proximity Read ↗

PIN-1 promoter polymorphisms in mild cognitive impairment and susceptibility to Alzheimer's disease: a preliminary report.Semantic proximity Read ↗

Pin1: A New Genetic Link between Alzheimers Disease, Cancer and AgingSemantic proximity Read ↗

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.Semantic proximity Read ↗

Pin1 Regulatory miRNAs as Novel Candidates for Alzheimer’s Disease TreatmentSemantic proximity Read ↗

Promoter methylation and gene expression of Pin1 is associated to the risk on Alzheimer’s disease in Southern ChineseSemantic proximity Read ↗

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