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Article

PIN-1 promoter polymorphisms in mild cognitive impairment and susceptibility to Alzheimer's disease: a preliminary report.

Aging clinical and experimental research - 1 Oct 2007

Arosio Beatrice, Segat Ludovica, Milanese Michele, Galimberti Lorenza, Calabresi Carmen, Zanetti Mariella, Trabattoni Daria, Annoni Giorgio, Crovella Sergio, Vergani Carlo

Abstract excerpt

BACKGROUND AND AIMS: Peptydil prolyl cis-trans isomerase (PIN-1), which specifically regulates the conformational changes following phosphorylation of several proteins, targets the inactive hyper-phosphorylated tau on the Thr231-Pro motif and directly restores its biological function. Interesting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18007120
DOI: 10.1007/BF03324722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18007120-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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