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Article

A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.

Neurobiology of aging - 1 Apr 2012

Ma Suk Ling, Tang Nelson Leung Sang, Tam Cindy Woon Chi, Lui Victor Wing Cheong, Lam Linda Chiu Wa, Chiu Helen Fung Kum, Driver Jane Ann, Pastorino Lucia, Lu Kun Ping

Abstract excerpt

Alzheimer's disease (AD), the most common form of dementia, is characterized by the presence of neurofibrillary tangles composed of tau and senile plaques of amyloid-beta peptides (Aβ) derived from amyloid precursor protein (APP). Pin1 is a unique prolyl isomerase that has been shown to protect against age-dependent neurodegeneration by acting on phosphorylated tau and APP to suppress tangle formation and...

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Source

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Identifiers

PMID: 20580132
DOI: 10.1016/j.neurobiolaging.2010.05.018
PMCID: PMC2988914

Genes

APP
PIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.PMID 20580132Read ↗

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