Article
Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease.
Neuroscience letters - 23 May 2007
Nowotny Petra, Bertelsen Sarah, Hinrichs Anthony L, Kauwe John S K, Mayo Kevin, Jacquart Sarah, Morris John C, Goate Alison
Abstract excerpt
Alzheimer's disease (AD) pathology is associated with two proteins, the microtubule-binding protein tau and the beta-amyloid-precursor protein (APP). When tau becomes hyperphosphorylated, it forms neuritic aggregates, called neurofibrillary tangles. APP is cleaved by several enzymes to generate Abeta peptides, which are - depending on their length - more or less amyloidogenic and form senile plaques. Pin1, a...
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