Article
Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data.
Genetic epidemiology - 1 Jan 2008
Kim Yoonhee, Duggal Priya, Gillanders Elizabeth M, Kim Ho, Bailey-Wilson Joan E
Abstract excerpt
Because most multipoint linkage analysis programs currently assume linkage equilibrium between markers when inferring parental haplotypes, ignoring linkage disequilibrium (LD) may inflate the Type I error rate. We investigated the effect of LD on the Type I error rate and power of nonparametric m...
Topics
- Computer Simulation
- Genetic Linkage
- Genetic Markers
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Parents
- Pedigree
- Statistics, Nonparametric