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Article

[Epidermal growth factor receptor mutation in Chinese patients with non-small cell lung cancer].

Ai zheng = Aizheng = Chinese journal of cancer - 1 Aug 2005

Pan Zhen-Kui, Zhang Li, Zhang Xing, Wang Xin, Li Ning, Xu Fei, Chang Jian-Hua, Guan Zhong-Zhen

Abstract excerpt

BACKGROUND & OBJECTIVE: Recent studies showed that somatic mutations in epidermal growth factor receptor (EGFR) tyrosine kinase (TK) domain are associated with sensitivity of non-small cell lung cancer(NSCLC) to TK inhibitor gefitinib. The mutations, including in-frame deletions at exon 19 and substitutions at exon 18 or exon 21, cluster around ATP-binding pocket of TK domain. The frequency of mutations are...

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Identifiers

PMID: 16086866

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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