Article
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Feb 2007
Liu Feng, Jiang Bin, Gong Sheng-ji, Yao Bao-di, Zhang Wen-ying, Zhu Guan-shan, Zhu Zhong-zheng, Gong Yu-fang, Wang Mei-ling, Hu Xiao-hua
Abstract excerpt
OBJECTIVE: To investigate gene mutations of the epidermal growth factor receptor (EGFR) and K-RAS in Chinese non-small cell lung cancers (NSCLCs). METHODS: Mutations of exons 18, 19 and 21 of the EGFR and codons 12, 13 of the K-RAS in 101 NSCLCs were detected by PCR-amplifying and gene sequencing, and the relationship between mutations and clinical characters of NSCLCs and response to gefitinib were analyzed....
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