Article
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Sept 2010
Sun Lei-na, Luan Huan-ling, Zang Feng-lin, Wang Meng, Dong Na, Guo Yan, Sun Bao-cun, Zhan Zhong-li
Abstract excerpt
OBJECTIVE: To investigate gene mutations of epidermal growth factor receptor (EGFR) and K-ras in Chinese patients with non-small cell lung cancer (NSCLC) and its clinicopathological significance, and to analyze the correlation between these mutations and tumor response to erlotinib treatment. METHODS: Mutations of exons 18, 19, 20 and 21 of the EGFR and codons 12, 13 of the K-ras in 301 cases of NSCLC were...
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